BOSTON — As surgeons here sliced through tissue surrounding a failed
artificial hip in a 53-year-old man, they discovered what looked like a
biological dead zone. There were matted strands of tissue stained gray
and black; a large strip of muscle near the hip no longer contracted Dr. Young-Min Kwon, the lead orthopedic surgeon on the operation, said
the damage was more extensive than tests had indicated and might be
permanent. “The prognosis is guarded,” Dr. Kwon said Similar scenes are playing out at hospitals nationwide as a growing
number of patients seek to have faulty metal-on-metal artificial hips
removed and replaced. More than a decade ago, some researchers had
warned that the hips shed tiny pieces of metallic debris that posed
potential health threats to patients. But those warnings were not
heeded, and now doctors and patients face a growing public health
problem as one of the country’s biggest medical device failures unfolds 
..Some patients with all-metal hips — ones in which the cup and ball of a
joint is made of metal — said they had been bounced from doctor to
doctor who did not have the knowledge or the tools to properly diagnose
the problem. And by the time they reach specialists like Dr. Kwon at
Massachusetts General Hospital, potentially lasting damage may have
already taken plac
Dr. Kwon’s recent patient, Robert Cartier, said he saw seven doctors over the course of a year who told him not to worry or who gave him shots for his pain. Diagnostic tests also did not point to a problem. Only recently have researchers determined that such scans need to be run in a specific way to detect the extent of metal-related damage.
“It really didn’t get picked up early. I picked it up,” Mr. Cartier said, adding that he learned of Dr. Kwon while researching metal hip problems on the Internet. “It is like buyer-beware kind of stuff, you are trusting the doctors.”
All orthopedic implants, regardless of their composition, shed debris as they wear. But researchers say they believe that the particles released by some all-metal hips pose a special threat because scavenger cells dispatched by the body to neutralize the debris convert it into biologically active metallic ions. In some patients, a chain reaction begins that can destroy tissue and muscle.
For researchers like Dr. Kwon, the challenge is to identify both those patients most at risk and the best ways to monitor them.
So far, only a small fraction of the estimated 500,000 people in this country who received an all-metal hip over the last decade have suffered injuries. But studies suggest that those numbers will grow and that tissue destruction is occurring silently in some patients who have no obvious symptoms like pain.
“What we are seeing is a complex phenomenon,” Dr. Kwon said.
A recent study in England found that all-metal hips were failing early at three times the rate of hips made from metal-and-plastic components, which can last 15 years or more. Most people recover well from a device replacement procedure, but specialists like Dr. Kwon are also seeing growing numbers of patients with complications.
Over the last year, his caseload has tripled and other specialized hospitals like Rush University Medical Center in Chicago have also seen cases. In the first six months of this year, the Food and Drug Administration received more than 5,000 reports about problems with the all-metal hips, according to a recent analysis by The New York Times.
In May 2010, Mr. Cartier, an electrical contractor who lives in Manchester, N.H., got an all-metal hip on his right side when he underwent a procedure known as “resurfacing,” an alternative to traditional hip replacement intended to provide more mobility. A similar procedure performed in 2009 on his left hip appeared to have gone well, but the more recent operation left him in pain.
Frustrated with advice from doctors, he took the trip to Boston to see Dr. Kwon. In 2007 the surgeon had arrived as a fellow at Oxford University in England just as problems with all-metal hips were emerging in England and Australia, two countries where the implants were used earlier than the United States. Since then, he has become a co-author of several studies linking metallic debris and aberrant tissue growth
..Some patients with all-metal hips — ones in which the cup and ball of a
joint is made of metal — said they had been bounced from doctor to
doctor who did not have the knowledge or the tools to properly diagnose
the problem. And by the time they reach specialists like Dr. Kwon at
Massachusetts General Hospital, potentially lasting damage may have
already taken plac Dr. Kwon’s recent patient, Robert Cartier, said he saw seven doctors over the course of a year who told him not to worry or who gave him shots for his pain. Diagnostic tests also did not point to a problem. Only recently have researchers determined that such scans need to be run in a specific way to detect the extent of metal-related damage.
“It really didn’t get picked up early. I picked it up,” Mr. Cartier said, adding that he learned of Dr. Kwon while researching metal hip problems on the Internet. “It is like buyer-beware kind of stuff, you are trusting the doctors.”
All orthopedic implants, regardless of their composition, shed debris as they wear. But researchers say they believe that the particles released by some all-metal hips pose a special threat because scavenger cells dispatched by the body to neutralize the debris convert it into biologically active metallic ions. In some patients, a chain reaction begins that can destroy tissue and muscle.
For researchers like Dr. Kwon, the challenge is to identify both those patients most at risk and the best ways to monitor them.
So far, only a small fraction of the estimated 500,000 people in this country who received an all-metal hip over the last decade have suffered injuries. But studies suggest that those numbers will grow and that tissue destruction is occurring silently in some patients who have no obvious symptoms like pain.
“What we are seeing is a complex phenomenon,” Dr. Kwon said.
A recent study in England found that all-metal hips were failing early at three times the rate of hips made from metal-and-plastic components, which can last 15 years or more. Most people recover well from a device replacement procedure, but specialists like Dr. Kwon are also seeing growing numbers of patients with complications.
Over the last year, his caseload has tripled and other specialized hospitals like Rush University Medical Center in Chicago have also seen cases. In the first six months of this year, the Food and Drug Administration received more than 5,000 reports about problems with the all-metal hips, according to a recent analysis by The New York Times.
In May 2010, Mr. Cartier, an electrical contractor who lives in Manchester, N.H., got an all-metal hip on his right side when he underwent a procedure known as “resurfacing,” an alternative to traditional hip replacement intended to provide more mobility. A similar procedure performed in 2009 on his left hip appeared to have gone well, but the more recent operation left him in pain.
Frustrated with advice from doctors, he took the trip to Boston to see Dr. Kwon. In 2007 the surgeon had arrived as a fellow at Oxford University in England just as problems with all-metal hips were emerging in England and Australia, two countries where the implants were used earlier than the United States. Since then, he has become a co-author of several studies linking metallic debris and aberrant tissue growth
RIYADH — Two in 10 persons suffer from diabetes in Saudi Arabia and the prevalence of diabetes has reached an alarming rate of 20 percent, said Ian Campbell, a visiting professor currently engaged in giving lectures on diabetes in major Saudi cities.